49ers vs Jaguars Predictions & Best Bets

Last Updated: Nov 7, 2023

After winning their first five games to start off the 2023 NFL season, the San Francisco 49ers have since dropped three straight. They’ll try to get back on track with a road victory against Trevor Lawrence and the 6-2 Jacksonville Jaguars.

In contrast to the 49ers, the Jaguars have now won five consecutive games after starting the season 1-2 and have established themselves as one of the best teams in the AFC. Could this be a potential Super Bowl preview in Week 10?

49ers vs Jaguars Odds

NFL odds used for this San Francisco vs Jacksonville preview were found at FanDuel Sportsbook and are current as of Tuesday, Nov. 7, at 10:30 ET.

  • Moneyline: 49ers (-164) • Jaguars (+138)
  • Spread: 49ers -3 (-110) • Jaguars +3 (-110)
  • Total Points: Over 44.5 (-115) • Under 44.5 (-105)
  • Implied Score: 49ers 23.5, Jaguars 21.5

49ers vs Jaguars Predictions

Score Pick: Jaguars 27, 49ers 20

The Jaguars have been rolling ever since the division-rival Houston Texans beat them 37-17 in Week 3. They’ve now defeated five straight opponents by an average margin of victory of 11.0 points per game.

Travis Etienne Jr. has been the driving force for the Jacksonville offense in recent weeks, scoring seven touchdowns in the team’s last four games. Expect him to be featured early and often as the Jaguars look to keep pace with the Baltimore Ravens and Kansas City Chiefs atop the AFC standings in hopes of securing a playoff bye.

49ers vs Jaguars Best Bets & Props

Jaguars +3 (-108)

DraftKings Sportsbook • WAGER: 2 units

Lawrence and the Jaguars continue to find ways to win. Yet they’re being given three points on their home field against a team that has lost three in a row. They have covered the spread in each of their past five games and now face a 49ers team that has failed to exceed 17 points in their previous two road games.

The Jaguars can win this game outright, so getting three points when backing them makes this my NFL bet of the day.

Jaguars Over 2.5 Total Touchdowns (+110)

DraftKings Sportsbook • WAGER: 1 unit

During the Jaguars’ five-game win streak, the offense has been firing on all cylinders. In that span, they have scored at least three touchdowns in three games. Etienne has actually been a TD away from eclipsing this total individually in three of the last four games, which bodes well for the Jaguars’ chances of doing so as a unit.

Coming off a bye in Week 9, head coach Doug Pederson will have had two weeks to prepare his team for this showdown with the 49ers. Expect him to have his offense primed to score three-plus touchdowns.

Jaguars Over 25.5 (+195)

DraftKings Sportsbook • WAGER: 0.5 units

As previously mentioned, the Jaguars have been red hot offensively during their winning streak and will have an opportunity to keep it rolling in Week 10. They’ve averaged a gaudy 27.2 points per game over their past five and are now expected to add trade-deadline acquisition Ezra Cleveland to their offensive line.

Given the odds, this is great value and a worthy investment to make in a team that was playing its best football of the season before the Week 9 bye.

49ers vs Jaguars Same Game Parlay

49ers vs Jaguars SGP (+267)

DraftKings Sportsbook • WAGER: 0.5 units

  • Jaguars +3 (-108)
  • Over 45 (-110)

Although the 49ers failed to score more than 17 points in each of their past two contests, they still rank fourth in the league in points per game (27.3). This is an elite offense that’s filled with playmakers and could potentially be welcoming back former All-Pro wide receiver Deebo Samuel.

The Jaguars have not only won each of their past five games, but they’ve also covered the spread in all of them. Expect more of the same in this potential Super Bowl preview between two of the NFL’s best teams.


Lior Lampert

Lior is an NBA/NFL writer for The Game Day. He earned a BA in English and MS in Sports Analytics in Management during his time as a student. Since then, Lior has been writing content for FanSided, GMEN HQ, and GameTime Sharks among other pages regarding the NFL, NBA, Tennis, fantasy football, and sports betting to develop a career in the sports media industry. Born in Israel but raised in New York, Lior is a long-time fan of his hometown New York Knicks and Giants. Not only does he enjoy covering sports, he enjoys playing basketball, tennis, and pickleball.

Related articles


Get $1,500 in Bonus Bets

5 stars

Bet $5, Get $150 in Bonus Bets or First Bet Safety Net

5 stars

Get A $1,500 No Sweat Bet + NBA SGP Token

5 stars

Get A Bonus Bet Up to $1,000

5 stars

Bet $5, Get $150 in Bonus Bets

5 stars

Get Up To $250 Second Chance Bonus Bet

5 stars

If you or someone you know has a gambling problem and wants help, please call 1-800-GAMBLER.

21+ and present in OH. Gambling Problem? Call or text 1-800-GAMBLER (CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY).

Call 877-8-HOPENY or text HOPENY (467369) (NY).

Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI).

All betting content on is exclusively intended for audience members 21 years and older who are permitted to gamble in legal states. The Game Day may earn revenue from site visitor referrals to betting services.

Responsible Gaming: Many sportsbooks offer ways to encourage responsible gaming, including the establishment of limits to deposits, spending, and time dedicated to betting.

The Game Day is a TGD Marketing Ltd. endeavor.