49ers Cowboys Bet Tips for Week 15

Last Updated: Jan 8, 2021

The San Francisco 49ers visit the Dallas Cowboys at AT&T Stadium on Sunday at 1 p.m. ET. Here’s our complete guide to 49ers Cowboys Bet Tips. Odds and lines for 49ers-Cowboys picks are from PointsBet, current as of Thursday at 5:00 p.m. ET.

San Francisco 49ers (5-8) at Dallas Cowboys (4-9)

49ers Cowboys Bet Tips

Odds & Betting Lines for 49ers-Cowboys Picks

  • Against The Spread: 49ers -3 (-110)/Cowboys +3 (-110)
  • Moneyline: 49ers (-160)/Cowboys (+135)
  • Total: 45 — Over 45 (-115)/Under 45 (-105)
  • Implied Team Totals: 49ers 24, Cowboys 21

This game features two teams that are not mathematically eliminated from postseason contention, but they might as well be. In fact, the loser of this game could ultimately put a fork in their lost seasons. Just think, back in August, many had the 49ers and Cowboys in their Super Bowl picks. Now, they play for draft positioning. The 49ers are 1-5 in their past six games, but currently on a two-game losing streak while the Cowboys are 2-2 in their past four games, ending a two-game slide of their own with last week’s win over Cincinnati.

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49ers-Cowboys Team Key Injuries


The 49ers have two key offensive pieces on the injury report this week WR Deebo Samuel is dealing with a hamstring injury and will miss some time. Head coach Kyle Shanahan previously told the press that Samuel will be sidelined for “a while."

With Samuel out indefinitely, look for Brandon Aiyuk, Kendrick Bourne, and Richie James to pick up the pace. All three players have flashed this season, but Aiyuk, an upside rookie, has been the best of the group without Samuel.

RB Raheem Mostert has yet to practice this week after suffering an ankle injury in last week’s loss to Washington. If Mostert is ruled out for Sunday’s matchup at Dallas, Jeff Wilson will likely be the primary rusher for the 49ers.

Even with Mostert healthy recently, Wilson has drawn touches. Wilson has garnered 12+ touches in three of his past four games but has lost two fumbles in his past three games. If Wilson logs another turnover, the 49ers may have to move off of Wilson.


Cowboys RB Ezekiel Elliott remains on the injury report with a calf issue. The upside rusher was also dealing with the injury ahead of last week’s win over the Bengals but was not setback by it in the matchup. While Elliott was limited at Wednesday’s practice, he remains on track to suit up in Week 15. Elliott has never missed a game due to injury in his five-year career.

49ers-Cowboys Players to Watch

49ers WR Brandon Aiyuk has another opportunity to shine as the team’s No. 1 wideout with Deebo Samuel out.

Since Week 6, Aiyuk has played in six games. The talented rookie has gone for a touchdown or 100+ yards in all six of those outings. He’s also seen at least seven targets in five straight games, including three games over 10.

Now, Aiyuk gets a Cowboys secondary allowing the sixth-fewest passing yards per game (215.2) with a league-high 22 touchdowns to the position. Although yards look like they are hard to come by, it is more because the Cowboys allow the most rushing yards per game than anything else. Either way, you can gash Dallas at will.

49ers Cowboys Bet Tips and 49ers-Cowboys Picks: Brandon Aiyuk is one of the sleepers of the 2020 rookie wide receiver class
San Francisco 49ers wide receiver Brandon Aiyuk (11) celebrates a touchdown against the Buffalo Bills during the first half at State Farm Stadium. (USA TODAY Sports)

Aiyuk should blow up again this week.

If there has been one part of the Dallas offense that has been fairly consistent this season, it has been Amari Cooper. With or without Dak Prescott under center, Cooper has been productive.

Cooper has gone for at least six receptions for 80 yards or a touchdown in 10-of-13 games this season. He is currently riding a three-game streak with a touchdown.

While CeeDee Lamb could emerge as the WR1 in 2021 once Prescott — or an incoming rookie — is under center for Dallas, in 2020, Cooper is the guy.

Cooper will look to extend his scoring streak to four games facing a 49ers defense surrendering the fifth-fewest passing yards per game (210.3) this season with 15 touchdowns allowed to enemy wide receivers.

49ers-Cowboys Weather Report

The weather at AT&T Stadium calls for clear and sunny skies at the time of kickoff with a 0% chance of precipitation.

The temperature is set at 37 degrees Fahrenheit with 5 mph winds blowing North-Northwest.

49ers-Cowboys Picks & Best Bet

BEST BET: Over 45 (-115)

While the Under seems like the wiser wager, I am feeling the Over in this game. Although the Cowboys demolished the Bengals 30-7, the 49ers are a much better team even with Nick Mullens under center. And considering the Cowboys’ defense is terrible, especially defending the run, the 49ers could have an explosive day on offense.

The 49ers love to run the football. And even if Raheem Mostert does not play or is limited, Jeff Wilson has shown that he is talented enough to thrive in San Francisco’s system.

The Cowboys are allowing the most rushing yards per game (162.7) this season, which plays right into the 49ers’ hands. If San Francisco can get going running the ball, Mullens could have a big day passing.

The 49ers’ defense, usually a strength, has taken a tremendous step back this season. They are allowing the 14th fewest points per game (23.9). Normally, they are a top 10 unit when healthy. The Cowboys defense is lousy against the run, but they are also yielding the most PPG (30.8) as well.

The Over is 3-3 in the 49ers’ past six games, hitting the Under in two of their past three, including last week.

The Over is 3-1 in the Cowboys’ past four games, hitting the Under last week.

The Over is 3-2 in the past five meetings between the Cowboys and 49ers, hitting in their last matchup in 2017.

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CONSIDER: 49ers -3 (-110)

With the 49ers struggling, the Cowboys have a shot to win their second straight game. However, I will still err on the side of the road team. They are better coached and can run the ball with more efficiency. They also have a stout and opportunistic defense, especially when playing inferior foes in 2020.

The Cowboys’ Achilles heel this season has been their offensive line. The 49ers, despite injuries, can still rush the passer. They will get to Andy Dalton early and often on Sunday, which will be the difference in the game.

The Cowboys are 3-1-1 against the spread in their past five meetings with the 49ers.

The 49ers are 1-5 ATS in their past six games, failing to cover in each of their past two.

The Cowboys are 3-2 ATS in their past five games, covering last week against Cincy.

CONSIDER: 49ers (-160)

If you think this game will be closer than three points but think the 49ers will still win, then take their Moneyline at slightly worse odds.

Anthony Cervino is 48-40-1 on his NFL Best Bets in 2020.

Prepare Week 15 betting tips and plan

After studying 49ers Cowboys Bet Tips and 49ers-Cowboys Picks:


Anthony Cervino

Anthony Cervino is an NFL Writer and Betting Analyst for The Game Day. He is also a lifelong NFL savant and self-proclaimed league historian. In the industry, Anthony has excelled in both the fantasy football and sports betting space with fantasy his proverbial bread and butter. Anthony has made appearances on SiriusXM, amongst other publications. He is also the co-creator of the FF Faceoff (Faceoff Sports Network) and the FF Faceoff Mental Health Podathon partnered with the Hayden Hurst Foundation. Industry Clout: 15th most accurate ranker in the FantasyPros ECR for both draft and in-season accuracy (2019) | 8th most accurate ranker in the FantasyPros ECR for sleepers (2020) | 13th most accurate ranker in the FantasyPros ECR for in-season accuracy, including 2nd at quarterback and 3rd at tight end (2021).

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