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Michigan State vs USC Predictions | Odds & Best Bets

Last Updated: Mar 16, 2023

Michigan State begins its journey for the school’s third NCAA National Championship this Friday at the Nationwide Arena in Columbus, Ohio.

The East’s No. 7 seed is set to take on USC for an opportunity to advance to the Round of 32.

Read on for my Michigan State vs USC prediction and best bets.

Michigan State vs USC Odds

Note: CBB odds mentioned in this article for Michigan State vs USC were used from DraftKings Sportsbook, unless otherwise noted, and are current as of Tuesday, March 14, at 7 a.m. ET.

  • Moneyline: Michigan State (-130) | USC (+110)
  • Spread: Michigan State -2 (-110) | USC +2 (-110)
  • Total: Over 137.5 (-110) | Under 137.5 (-110)

Michigan State vs USC Best Bet

Keep reading for more Michigan State vs USC betting tips.

Michigan State vs USC Prediction

Michigan State 69, USC 68

This Friday afternoon matchup is already shaping up to be one of the most exciting games in the Round of 64. Both squads have had exceptional seasons, however, up to this point, the Spartans are arguably far more battle tested.

The Trojans certainly have a shot at an upset here, but Michigan State is easily the safer bet.


📈 Keep track of NCAA Tournament winner odds to find our best March Madness bets:


Michigan State vs USC Best Bets

Winning Margin: Either Team to Win by 5 or Less (+155) | DraftKings Sportsbook

WAGER: 2 Units

With how tight this game is currently expected to play out, Either Team to Win by 5 or Less at plus-money seems like a mistake.

You won’t find much parity when comparing the season-long stats of both squads. They both average just over 70 PPG, allowing 67 PPG to their opponents.

Barring a uber-hot shooting night from either team, this game should come down to the wire.

Under 137.5 (-110) | DraftKings Sportsbook

WAGER: 1 Unit

Neither offense greatly supersedes the other, and for that reason, the Under seems like the most likely outcome when betting this game.

Both squads are average to slightly above average in almost every major offensive statistic this season. The two teams both go through extended periods of cold shooting, and that trend should continue here with defensive intensity going up a notch.

Michigan State vs USC Same Game Parlay

Michigan State vs USC SGP (+130) | DraftKings Sportsbook

WAGER: 1 Unit

  • USC +2.5 (-120)
  • USC Total Points O66.5 (-210)

Michigan State vs USC SGP

As previously mentioned, USC certainly has a shot to steal this game and punch a ticket to the Round of 32. Utilizing DraftKings’ Same Game Parlay allows for another point and a half on the spread, which should cash fairly easily.

The Trojans averaged 72.8 PPG this season and should have no problem hitting the 66.5 mark selected.

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