Panthers vs Dolphins Predictions Week 12 | NFL Pick of the Day

Last Updated: Nov 22, 2021

If not for the return of quarterback Cam Newton, it would be quite difficult to get excited about this game.

In his first start back in a Panthers uniform, Newton threw for 189 yards and two touchdowns, and also rushed for 46 yards with an additional touchdown. The game ended in a 27-21 loss to the Washington Football Team, but it was a great first impression back.

While the Panthers are coming off a loss, the Dolphins are coming off a win, but it came against the New York Jets and Joe Flacco.

Both teams are hoping to turn a corner down the stretch. The Panthers (5-6) are a bit closer to a playoff berth than the Dolphins (4-7), but that could change this week in what the sportsbooks are deeming to be a close matchup.

Let’s dive in and sort this out.

Please note that all NFL gameday odds and lines are current as of 11 a.m. ET on Monday, November 22.

Panthers vs Dolphins Prediction

The Dolphins are coming off a win in Week 11, but they did only beat the Jets by seven points while allowing nearly 300 passing yards to Joe Flacco.

On paper, the Dolphins’ defense should be plenty better than it has been this season, but they have not lived up to the hype. Star cornerback Xavien Howard has surrendered seven touchdowns and nearly 500 yards.

Sportsbook Play of the Day

Before continuing our Dolphins vs Panthers betting tips, you should know that Caesars Sportsbook is among the industry’s best, offering tons of promotions and matching your first bet up to $1,001 (win or lose) for new signups using our promo code .

Read Chris Wassel’s Caesars Sportsbook review for more insight and get your welcome bonus below, or continue reading this analysis for our Dolphins vs Panthers tipster picks.

Conversely, the Panthers have actually performed well on defense overall. Cornerback Stephon Gilmore recently came back from injury and already has two interceptions. Edge rushers Haason Reddick and Brian Burns have also combined for nearly 20 sacks.

The Panthers being on the road could be a factor, but at the end of the day, the defenses are going to determine the outcome of this matchup, and I’ll side with the Panthers. Both offenses will be pretty slow to get going as evidenced by their Week 11 performances.

The Dolphins’ offensive line has trouble against any pass rush and the Miami defense may not have an answer for running back Christian McCaffrey.

Prediction: Panthers 20, Dolphins 17

Christian McCaffrey, RB, Carolina Panthers

Panthers running back Christian McCaffrey could be a matchup nightmare for the Dolphins defense in Week 12. (Image: USA TODAY Sports)

Panthers vs Dolphins Best Bets

Best Bet: Panthers Moneyline (-110) at Caesars

Wager: 1 Unit

Newton may only be making his second start since returning to the team and the Panthers are on the road, but I just have a hard time seeing how Carolina doesn’t win this game.

Remember, Newton did play for the New England Patriots and has recent experience against the Miami Dolphins. Sure, it’s a new year and team, but there are still some consistencies from year to year.

The offensive weapons also favor the Panthers, headlined by McCaffrey, but also supported by wide receiver D.J. Moore.

Dolphins quarterback Tua Tagovailoa has played pretty well overall this season, but his pass-catchers may have trouble getting open against a talented secondary that features Gilmore and A.J. Bouye, who has also been more than competent this season.

Best Bet: Under 42.5 Total Points (-110) at Caesars

Wager: 0.5 Units

Whenever you see a total at 42.5, it’s already easy to tell that the game should be low-scoring. And while going under 42.5 is pretty difficult in the modern NFL, that is where I’m leaning.

The Panthers may have better playmakers, but this is far from an elite offense. Meanwhile, the Dolphins may not be showing well from a production standpoint this year, but there is still plenty of talent there.

Miami does have trouble finding the end zone, though, and the rushing attack is greatly hampered by an atrocious offensive line. Wide receiver Jaylen Waddle has been a bright spot and should find some openings, but this is going to be a slow and low-scoring affair.

Thanks for reading our NFL Week 12 Panthers vs Dolphins Predictions! For more NFL betting tips, check out our Thanksgiving NFL Predictions and Best Bets.


Richard Janvrin

Before and after graduating from the University of New Hampshire with a degree in journalism, Richard spent time writing for Bleacher Report covering the NFL, MLB, and multiple other sports. Richard has written in the online casino/sportsbook space for nearly 3 years since his time at Bleacher Report. In his free time, Richard enjoys spending time with his son, creating content on his YouTube channel, and writing music.

Related articles


Welcome offer
Caesars Sportsbook

1st Bet on Caesars up to $1,250 + 2,000 in Rewards & Tier Credits

5 stars
Welcome offer
DraftKings Sportsbook

Bet $5 & Get $200 in Bonus Bets

5 stars
Welcome offer
bet365 Sportsbook

Bet $1 & Get $200 FREE

5 stars
Welcome offer
FanDuel Sportsbook

Get $2,500 No Sweat First Bet

5 stars
Welcome offer
BetMGM Sportsbook

Get up to a $1,000 First Bet Offer Bonus

5 stars
Welcome offer
Tipico Sportsbook

Get Up to a $100 Bonus

5 stars
Welcome offer
BetRivers Sportsbook

Get up to $250 2nd Chance Free Bet

5 stars
Welcome offer
WynnBET Sportsbook

Bet $100 & Get a $50 Free Bet + a $50 Casino Bonus

5 stars
Welcome offer

Get Up To $50 First Bet on FOXBet

5 stars