Texans vs Colts Predictions Week 6 | NFL Pick of the Day

The Texans still haven’t notched a win since their Week 1 defeat of the Jacksonville Jaguars, but they came very close in Week 5 before succumbing to the New England Patriots, 25-22.

Rookie quarterback Davis Mills turned in an outstanding out-of-nowhere effort that included 312 passing yards and three touchdowns, while receiver Chris Moore stepped up with an equally surprising 5-109-1 line.

The Colts lost in crushing fashion to the Baltimore Ravens on Monday night, allowing 16 fourth-quarter points to send the game to overtime and then yielding a 10-play, 68-yard scoring march during the extra period to drop a 31-25 decision.

Indy certainly put up plenty of encouraging offensive statistics in the loss as Carson Wentz posted a 402-yard, two-touchdown effort, while Jonathan Taylor contributed a 76-yard catch-and-run touchdown grab as part of a 3-116-1 line through the air.

However, the defense also gave up 523 total yards, a whopping 504 of them to Lamar Jackson (442 passing, 62 rushing).

Both teams will therefore be striving to get over major disappointments in this Week 6 AFC South showdown. Let’s take a closer look to see which side to take in this latest matchup in the NFL pick of the day series.

Please note that all NFL Week 6 odds and lines are current as of 5 PM EST on Friday, October 15.

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Texans vs. Colts Prediction

The Colts’ already nightmarish start to the season got exponentially worse with Monday night’s crushing blow.

Although there are plenty of encouraging signs on the offensive side of the ball as Wentz has progressively gotten healthier from his pair of ankle sprains, the defense has struggled to slow down any team not named the Miami Dolphins.

The secondary has been especially poor, as they have surrendered 15 touchdowns and only have 3 interceptions.

While Mills, as a rookie quarterback, could easily regress week-to-week, the command he displayed versus the scheme of an elite defensive mind like Bill Belichick in Week 5 certainly can’t be overlooked.

The Stanford product could very well be progressing with the more reps he gets, certainly not out of the question for a young player who was thrown into the fire when Tyrod Taylor went down with a hamstring injury just before halftime in Week 2.

The Colts should also be able to make plenty of inroads against the Texans’ defense, even as Houston is playing better overall on that side of the ball than in recent seasons.

David Culley’s squad is allowing a respectable 257.0 passing yards per game (225 per road game), although their work against opposing ground attacks requires more improvement (134.8 rushing yards per contest allowed).

Indy’s offense should be able to achieve balance, even if it starts a bit sluggishly due to the MNF hangover, with Taylor, who generated a 29-174-1 line on the ground and a 7-56-1 tally through the air versus the Texans in two games last season.

With Indianapolis playing on a rest disadvantage, I can see a tight, lower-scoring first half. However, Indy’s superior talent should rise to the top in the second half, allowing the Colts to pull away for a close home victory.

Prediction: Indianapolis Colts 27, Houston Texans 20

Carson Wentz, QB, Indianapolis Colts

Carson Wentz continues to improve throughout the season, and following a heartbreaking Monday Night Football loss, the Indianapolis Colts look to bounce back against the Houston Texans. (Image: USA TODAY Sports)

Texans vs. Colts Best Bets

Best Bet: Texans +10 (-110) at BetMGM



Houston Texans +10 (HOU @ IND, NFL Week 6)

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As already highlighted, the Colts will certainly be at what would have to be considered a significant rest disadvantage for this contest and continue to deal with key injuries on defense.

Meanwhile, the Texans have to have built some confidence in both Mills and their offense in general with Sunday’s performance.

While I predict an Indy win as noted above, I don’t necessarily think it will be a blowout victory, and this is a large number. The Colts are also just 10-10-1 as a home favorite since Frank Reich took over the head coaching reins in 2018.

Best Bet: Over 43.5 (-110) at Caesars



Over 43.5 Total Points (HOU @ IND, NFL Week 6)

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The Texans are allowing 28.2 points per contest, while the Colts aren’t far behind them with 25.6 per game allowed. What’s more, those figures bump up to 35.5 and 27.5, respectively, when utilizing the home/road splits that apply in Week 6.

Wentz certainly showed he’s getting increasingly healthier and more comfortable with his new teammates in Monday night’s shootout in Baltimore, while Mills has a growing rapport with Moore and Chris Conley, in addition to the explosive Brandin Cooks.

This number is a very low threshold to clear as well, putting me in the camp of the Over.

Best Bet: Texans Over 16.5 (-105) at BetMGM



Houston Texans Over 16.5 Total Points (HOU @ IND, NFL Week 6)

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The Texans managed just nine points in Mills’ first two games as a starter (they all actually came in a Week 3 loss to the Panthers) before Sunday’s improved effort against the Patriots.

Mills and Houston’s stable of veteran backs should be able to get to at least 17 points in this spot against what could once again be a short-handed Colts defense and is sure to be a bit of a fatigued unit after the OT loss Monday night.

Indianapolis has also allowed at least 25 points in four of its first five games, and they gave up 17 to the Dolphins in the one instance in which they fell under that number.

Thank you for reading our NFL Week 6 Texans vs. Colts Predictions! For more NFL betting tips, check out our NFL Week 6 Best Bets and NFL Week 6 Parlays Picks.

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NBA Betting News

  • Celtics +300 to win NBA Title

    The Boston Celtics are +300 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics are +300 ahead of their home date with the Warriors for Game 6. We will see a considerable odds shift if the Celtics can win Game 6 on their homecourt. Boston was +310 after Game 5.

  • Celtics vs. Warriors over/under listed at 210

    The over/under for Game 6 of the NBA Finals between the Boston Celtics and the Golden State Warriors is listed at 210, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210, down from the 210.5 it opened at. 60 percent of the public action has come on the over.

  • Warriors -400 to win NBA Championship

    The Golden State Warriors are -400 to win the NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    Golden State now sits at a prohibitive -400 to win the NBA Championship. For comparison, Stephen Curry MVP is -360. Andrew Wiggins, the dark horse to steal the award with a big close-out game, sits at +2000.

  • Celtics +310 to win NBA Championship

    The Boston Celtics are +310 to win the 2021-22 NBA Championship, per BettingPros consensus odds.

    Betting Impact:
    The Celtics peaked as high as high as -230 prior to Game 3 and now sit at an attractive +310. Boston entered the season at +4000. The odds could swing wildly again if Boston wins Game 6.

  • Warriors vs. Celtics over/under listed at 210.5

    The over/under for Game 5 of the NBA Finals between the Golden State Warriors and the Boston Celtics is listed at 210.5, per BettingPros consensus odds.

    Betting Impact:
    The total for this contest sits at 210.5, down from the 212.5 it opened at. 72 percent of the public action has come on the over.