NFL Preseason Week 1 Parlays, Picks + Predictions – NFL Play of the Day

Frank AmmiranteSenior Sports Writer
Last Updated: Aug 5, 2021

NFL Preseason Week 1 Parlays, Picks + Predictions - NFL Play of the Day

The NFL Preseason is difficult to bet on because it’s unclear which players will actually suit up for the game, especially in Week 1. I decided to approach this week by focusing on teams with more at stake, whether it’s because of a new head coach trying to make a strong first impression or if there’s an important position battle that needs to be resolved.

Want to start betting on sports during the Week 1 of the NFL Preseason? BetMGM offers new players a Risk-Free Bet of up to $600.

  • to claim BetMGM’s welcome promotion.
  • Learn more about BetMGM with our hands-on sportsbook review.

Best NFL Parlays Week 1

Detroit Lions +2 (-110) vs. Buffalo Bills

Atlanta Falcons +1 (-110) vs. Tennessee Titans

New Orleans Saints +2.5 (+100) @ Baltimore Ravens

The Detroit Lions make their debut with new head coach Dan Campbell. They’re taking on a Bills team that is a Super Bowl contender with nothing really to play for here. On the other hand, the Lions have several new players on the roster looking to make an impression on a new coaching staff. You can bet that Campbell will push for a win with his new team. He seems intent on setting the tone with a culture change in Detroit.

Like the Lions, the Atlanta Falcons will be playing their first game under new head coach Arthur Smith. Smith gets to face his former team in the Tennessee Titans, where he worked in several roles since 2011. The Titans are a team that should make the playoffs, while coach Smith can try to stick it to his former colleagues with a win here. The Falcons have more at stake in this game.

The New Orleans Saints are a team in transition with a battle between Jameis Winston and Taysom Hill at starting quarterback. There’s a decent chance that we’ll see both quarterbacks in this game. On the other side, the Baltimore Ravens are another Super Bowl contender, so this game obviously means less to them. Bet on the team with the quarterback competition.

NFL Week 1 Longshot Parlay Prediction

Atlanta Falcons (+100) vs. Tennessee Titans

New Orleans Saints (+120) @ Baltimore Ravens

Cincinnati Bengals (+200) @ Tampa Bay Buccaneers

Jacksonville Jaguars (+230) vs. Cleveland Browns

Detroit Lions (+110) vs. Buffalo Bills

Five-team parlays are longshots, so it makes sense to take my three point spread wagers and play them on the moneyline as well. I also added the Cincinnati Bengals, who are 6-point underdogs against the defending Super Bowl champion Tampa Bay Buccaneers. The Bucs are returning several of their starters from last year with not many position battles, so it’s worth it to take a shot on the underdog.

The Jacksonville Jaguars are also facing a Super Bowl contender in the Cleveland Browns, with new head coach Urban Meyer starting off his tenure with the Jags. No team should be such heavy underdogs in Week 1, so we’ll capitalize on the value here.

Same Game Parlay Picks Week 1

Cincinnati Bengals +6 (-110) @ Tampa Bay Buccaneers

Bengals/Buccaneers Over 33.5 (-110)

There’s simply no way that a team should be laying six points in Week 1 of the preseason. There are just too many variables to consider, such as which players are players and for how long. The Bengals have more at stake in this game, as the Bucs roster is pretty much settled. They should be able to cover this spread.

I’m also adding the over on the 33.5-point total here, simply because it’s just too low of a number. This game can finish 20-14 and we would still clear the over, which really sets a low bar. While we can’t expect a shootout in the first week of the preseason, it’s hard to move away from this over while it’s so low.


Frank Ammirante

Frank Ammirante is a Senior Sports Writer at The Game Day. Previously, he wrote for 4for4 Football and RotoBaller. Frank is a member of the Fantasy Sports Writer's Association while maintaining an active presence within the community. He has competed in industry contests like the Scott Fish Bowl, The Great Fantasy Baseball Invitational, and more. Frank will be making his debut in Tout Wars this year. He's got a diverse sporting background, but specializes in football and baseball.

Related articles


Welcome offer
Caesars Sportsbook

1st Bet on Caesars up to $1,250 + 2,000 in Rewards & Tier Credits

5 stars
Welcome offer
DraftKings Sportsbook

Bet $5 & Get $200 in Bonus Bets

5 stars
Welcome offer
bet365 Sportsbook

Bet $1 & Get $200 FREE

5 stars
Welcome offer
FanDuel Sportsbook

Get $1,000 No Sweat First Bet

5 stars
Welcome offer
BetMGM Sportsbook

Get up to a $1,000 First Bet Offer Bonus

5 stars
Welcome offer
Tipico Sportsbook

Get Up to a $100 Bonus

5 stars
Welcome offer
BetRivers Sportsbook

Get up to $500 2nd Chance Free Bet

5 stars
Welcome offer
WynnBET Sportsbook

Bet $100 & Get a $50 Free Bet + a $50 Casino Bonus

5 stars
Welcome offer

Get Up To $50 First Bet on FOXBet

5 stars