NFL DFS Best Picks Week 5 | PrizePicks Lineups and Sleepers

Last Updated: Oct 8, 2021

Week 5 kicked off with another exciting Thursday Night Football matchup featuring the Seattle Seahawks and Los Angeles Rams. However, we saw both quarterbacks in that game suffer hand injuries. While it’s a part of the game, we are seeing injuries to key players stack up quite quickly this season.

If you’d like to limit the negative impact that injuries may have on your fantasy football fun, playing Daily Fantasy Sports may be a good route for you. DFS or sports betting is also an easy way to inject some excitement into the less riveting matchups on the NFL slate.

If you’re looking for a way to combine the fun of betting and fantasy, PrizePicks may be the perfect site for you.

Unlike the typical salary cap lineup construction format that most DFS sites follow, PrizePicks has users build their own parlays by selecting Over or Under on up to five specific player props instead. The more props you select, the higher the multiplier on the entry fee.

Another plus about PrizePicks is their Flex Play option, which allows users to win even with missed picks, though it lowers the potential payout for perfect picks.

Now that you understand how PrizePicks works, let’s get into the DFS football predictions series for Week 5!

Stat information for NFL DFS Week 5 picks are current as of Friday, October 8, at 12 PM ET.

NFL Week 5 Best Player Prop Bets

Check out the best player prop bets this week with our props comparison tool, including projections to help you make the best decisions. Click “Place Bet" to unlock the associated sportsbook’s welcome offer and place your bet. Select the game you want to highlight, including this week’s highly-anticipated matchup between the Buffalo Bills and Kansas City Chiefs.

Learn more about NFL prop bets and the best sportsbooks for prop betting.

NFL DFS Week 5: Single-Stat Daily Fantasy Sports

With the single-stat game format, users will pick Over or Under for a player’s performance in a single stat. Users can string picks together across different games and sports.

Sam Darnold, QB, Carolina Panthers

Over 250.5 Passing Yards

This season, Sam Darnold has been as consistent as they come for passing yard totals. He has finished between 279 and 305 yards in every game, with each of the past three games being above 300 yards.

Darnold faces the Eagles this week, who allow the fourth-highest completion percentage (72.73%) in the NFL. With the spread for this game only being three points, it is expected to be a competitive game, and Darnold should pass quite a bit yet again.

Taylor Heinicke, QB, Washington Football Team

Over 250.5 Passing Yards

Washington and Taylor Heinicke face the Saints this week. The New Orleans run defense is tough, which has led to opponents passing on them. This is why Daniel Jones topped 400 yards last week, while Mac Jones passed for 270 the week prior.

Coming off a 290-yard game, Heinicke should pass early and often, especially with their running game failing to have much consistent success.

Damien Harris, RB, New England Patriots

Over 0.5 Rushing TDs

After back-to-back terrible matchups and performances for Damien Harris, this is shaping up to be one of those Patriots running back games where the lead back falls into the end zone multiple times.

Harris is the team’s go-to red zone running back, as he’s had seven carries in the red zone, whereas no other running back has more than two. Harris also has three carries inside the five-yard line, and no other running back has gotten one.

Facing a bad Texans team, the Patriots should get in scoring position often, leading to a high touchdown probability for Harris.

Sam Darnold, QB, Carolina Panthers

Carolina Panthers QB Sam Darnold has gotten off to a hot start with his new team, exceeding 300 passing yards in multiple games. (Image: USA TODAY Sports)

Sportsbook Play of the Day

Before checking out the rest of our fantasy football picks of the day, consider signing up at PrizePicks! PrizePicks is a user-friendly platform that features a wide array of games, easy-to-understand contest formats, and an excellent first deposit match of up to $100 when you use our code to sign up.

Read Juan Carlos Blanco’s PrizePicks review for more insight and fantasy football tips get your welcome bonus below, or continue reading our fantasy football tipster picks.

NFL DFS Week 5: Fantasy Score Game

The Fantasy Score Game format follows the same concept as the Single-Stat Game. However, instead of picking a player’s performance in a stat category, users will pick Over or Under a player’s fantasy point total. For NFL DFS, PrizePicks follows a PPR scoring format.

Cordarrelle Patterson, RB, Atlanta Falcons

Over 13.5 Fantasy Points

Cordarrelle Patterson has been the Falcons’ best offensive player through the first month of action. Lining up as both a running back and wide receiver, he brings the skills a versatility a bad team needs.

His role should be even larger this week, due to Calvin Ridley and Russell Gage both being out.

The fact that Patterson scored three touchdowns last week should also be a reason for an expanded role. He has scored over 13.5 fantasy points in two of the past three weeks.

Daniel Jones, QB, New York Giants

Over 20.5 Fantasy Points

Coming off a 26.8-fantasy point day, Daniel Jones gets a matchup against the Dallas Cowboys, who surrender the third-most fantasy points to quarterbacks this season (28.5).

Jones has put up over 20.5 fantasy points in three of his four games this season. The big reasons are him limiting turnovers and Jones using his legs a bit more.

He is averaging 7.7 fantasy points per game with only his legs, giving him a high floor and an easier route to hit this Over.

Laviska Shenault, WR, Jacksonville Jaguars

Over 12.5 Fantasy Points

Last week, D.J. Chark was lost for the season. This resulted in Laviska Shenault being heavily targeted, much like he was in the preseason.

He caught six passes for 99 yards, while also rushing for 11 yards. The Jaguars have already said he will have a larger role going forward, which is good news for this prop.

It’s also good news that he faces the Tennessee Titans, who have given up the second-most fantasy points to wide receivers this season (52.8).

Thanks for reading our NFL Week 5 Best DFS Picks! For more NFL betting tips, check out our NFL Week 5 Best Prop Bets.


Zach Brunner

Zach Brunner has worked in the fantasy sports and sports betting industries for almost a decade now. He is the owner of FlurrySports and has experience working with FantasyPros, Awesemo, BetWay and other sites. Living in Wisconsin, when Zach isn't drinking beer or shoveling snow, he loves all things Wisconsin sports and UFC.

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